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Symbol
Name
ID 		Casp3
caspase 3
MGI:107739
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Hyposmia
Spasticity
Bradykinesia
Tremor
Depression
Anxiety
Panic attack
Hallucinations
Apathy
Reduced social reciprocity
Impulsivity
Agitation
Restless legs
Cognitive impairment
Dementia
Frontal lobe dementia
Short attention span
Insomnia
Hyperreflexia
Dyskinesia
Dystonia
Gait imbalance
Postural instability
Abnormal autonomic nervous system physiology
Disease(s) Associated with CASP3
Parkinson's disease

Mouse Phenotypes
nervous system phenotype
decreased neuron apoptosis
abnormal olfactory sensory neuron morphology
abnormal cochlear hair cell morphology
abnormal outer hair cell stereociliary bundle morphology
fused outer hair cell stereocilia
cochlear inner hair cell degeneration
cochlear outer hair cell degeneration
cochlear hair cell degeneration
abnormal brain morphology
abnormal cerebellum development
abnormal cerebellum external granule cell layer morphology
abnormal olfactory bulb development
hydrocephaly
abnormal brainstem morphology
abnormal forebrain morphology
abnormal diencephalon morphology
abnormal olfactory bulb morphology
abnormal cerebellar granule layer morphology
abnormal cerebellar molecular layer
cochlear ganglion degeneration
encephalomeningocele
Availability Mouse Genotype
Casp3hith2/Casp3hith2
Casp3mldy/Casp3mldy
Casp3tm1Dsp/Casp3tm1Dsp
Casp3tm1Flv/Casp3tm1Flv *
Casp3tm1Kin/Casp3tm1Kin
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory